Genetic tests without prescription

The availability of genetic tests sold on the internet, in pharmacies, gyms and beauty salons, at relatively affordable prices, has stimulated demand, and more and more people choose to take one. It is not recommended to take genetic tests without prescription and...

Daily self-monitoring of blood sugar

Those diabetics who keep their blood sugar under control, through diet and medicine carrying a low risk of causing hypoglycaemia, should not be routinely required to self-monitor their blood sugar every day. In fact, there is no proof of significant benefit from the...

Contraceptive pill and thrombosis risk assessment

Upon reports of increased risk for the most recent, third-generation pills (which contain desogestrel or gestodene or drospirenone as a progestin), many gynaecologists have started prescribing a series of preliminary analyses to women who request the pill, with the...
The search for anti-insular cell antibodies (ICA) and anti-insulin antibodies (IAA) should not be performed in the case of suspected late-onset autoimmune diabetes (LADA) or gestational diabetes mellitus. Search instead simultaneously for anti-GAD, anti-IA2 and anti-ZnT8 antibodies.

The search for anti-insular cell antibodies (ICA) and anti-insulin antibodies (IAA) should not be performed in the case of suspected late-onset autoimmune diabetes (LADA) or gestational diabetes mellitus. Search instead simultaneously for anti-GAD, anti-IA2 and anti-ZnT8 antibodies.

The finding of even one antibody positivity among anti-GAD, anti-IA2 and anti-ZnT8 is a diagnostic criterion of LADA and suggests an autoimmune pathogenesis in gestational diabetes mellitus.
The search for anti-insular cell antibodies (ICA) and anti-insulin antibodies (IAA) should not be performed in the case of suspected late-onset autoimmune diabetes (LADA) or gestational diabetes mellitus. Search instead simultaneously for anti-GAD, anti-IA2 and anti-ZnT8 antibodies.

Invasive endoscopic investigation with multiple biopsies should not be performed in all patients suspected of autoimmune gastritis but only in those presenting with alteration of serum markers of gastric function (pepsinogen I and II, gastrin 17) and/or antibodies against gastric parietal cells (PCA) and anti-intrinsic factor (IFA). For the determination of PCA and IFA, the use of quantitative immunometric methods is preferable.

In the presence of gastric function compatible with atrophy and autoantibody positivity the suspicion is substantial and it is necessary to proceed to gastric biopsy.