Never administer antibiotics for perioperative prophylaxis before 60 minutes prior to surgical incision*; the ideal time is upon induction of anesthesia.

Type of practice


Perioperative antibiotic prophylaxis (PAP) is an effective measure for the prevention of surgical site infections (SSI), where indicated. However, its misuse significantly contributes to the total consumption of antibiotics in hospitals and it has been associated with increased antibiotic resistance of microorganisms as well as increased health care costs. Antibiotics administration within 30-60 minutes of skin incision provides an effective concentration of the drug in serum and tissues of surgical site, thus reducing postoperative infection risks.

* subject to exceptions.


1. European Centre for Disease Prevention and Control. Systematic review and evidence-based guidance on perioperative antibiotic prophylaxis.
2. SNLG 17. Antibioticoprofilassi perioperatoria nell’adulto. Linee guida 2008, aggiornamento 2011. Disponibile su:
3. World Health Organization. Antimicrobial Resistance Global Report on surveillance 2014. Disponibile su:

Attention. Please note that these items are provided only for information and are not intended as a substitute for consultation with a clinician. Patients with any specific questions about the items on this list or their individual situation should consult their clinician.