Don’t routinely use cancer-directed therapy for solid tumor patients with low performance status (3 or 4) or progressive after 2-3 therapeutic lines, but prioritize palliative care.

Type of practice


Topic Area

Medical Oncology

The anticancer treatments in general are likely to be ineffective in patients with solid tumors with the following characteristics: low performance status (3-4), no response to previous evidence-based therapies, not eligibility for a clinical trial, the absence of evidence of effectiveness of further treatment. Only exceptions are patients in which the functional limitations are due to non neoplastic pathological conditions resulting in a low PS or patients with disease characteristics (for example, genetic mutations) that suggest a high probability of response to therapy. The choice of avoid anticancer therapies must be sustained by appropriate palliative and supportive therapy (simultaneous care).


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Attention. Please note that these items are provided only for information and are not intended as a substitute for consultation with a clinician. Patients with any specific questions about the items on this list or their individual situation should consult their clinician.