Do not prescribe proton pump inhibitors (PPIs) during steroid therapy or for long periods in patients who exhibit dyspeptic symptoms.

Oct 17, 2018

Do not prescribe proton pump inhibitors (PPIs) during steroid therapy or for long periods in patients who exhibit dyspeptic symptoms.

Type of practice

Drugs

Age

Adult, Geriatric

Topic Area

Gastroenterology

There is no evidence supporting the routine use of proton pump inhibitors (PPIs) in patients diagnosed with functional dyspepsia or as prophylaxis against iatrogenic injury during treatment with corticosteroids. The main risk associated with discontinuing PPIs in patients undergoing treatment for acid-related disorders is the recurrence of symptoms. Therefore, the therapeutic goal should be the control of residual symptoms and the improvement of the patient’s quality of life.

Sources

1. Farrell B, Lass E, Moayyedi P, et al. Reduce unnecessary use of proton pump inhibitors. BMJ 2022;379:e06921.doi: 10.1136/bmj-2021-069211.
2. Ford AC, Mahadeva S, Carbone MF, et al. Functional dyspepsia. Lancet 2020;396:1689-1702. doi: 10.1016/S0140-6736(20)30469-4.
3. Strand DS, Kim D, Peura DA. 25 Years of Proton Pump Inhibitors: A Comprehensive Review. Gut Liver 2017;11:27-37. doi: 10.5009/gnl15502.

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Attention. Please note that these items are provided only for information and are not intended as a substitute for consultation with a clinician. Patients with any specific questions about the items on this list or their individual situation should consult their clinician.