Don’t prescribe antibiotic therapy to patients colonized by multi-resistant antibiotics microorganisms without signs of infection.

Type of practice


This indication takes origin from the difference between colonization and infection: the former consists in the simple demonstration of the presence of a germ; the latter in the demonstration of local and/or systemic signs of germ-dependent inflammation. Both patients colonized by multi-sensible and multi-resistant microorganisms do not have to receive antibiotic therapy as first line therapy. Treating with antibiotics these colonisations is not suggested both because the patient takes the drug without any reason and also because you increase the antibiotic resistance with negative effects on the possibility of curing the patient during time.


1) Indicazioni pratiche e protocolli operativi per la diagnosi, la sorveglianza e il controllo degli enterobatteri produttori di carbapenemasi nelle strutture sanitarie e socio-sanitarie Febbraio 2017 Regione Emilia Romagna
2) Katz MJ, Gurses AP, Tamma PD, Cosgrove SE, Miller MA, Jump RLP Implementing Antimicrobial Stewardship in Long-term Care Settings: An Integrative Review Using a Human Factors Approach..
3) ECDC EU Guidelines for the prudent use of antimicrobials in human health, 2017 pag. 15



Attention. Please note that these items are provided only for information and are not intended as a substitute for consultation with a clinician. Patients with any specific questions about the items on this list or their individual situation should consult their clinician.