Never administer antibiotics for perioperative prophylaxis before 60 minutes prior to surgical incision*; the ideal time is upon induction of anesthesia.

Never administer antibiotics for perioperative prophylaxis beyond 24 hours after surgery. Antibiotic prophylaxis should be limited to the perioperative period. The choice to continue prophylaxis beyond the first 24 postoperative hours is not justified.

Perioperative Antibiotic Prophylaxis (PAP) is an effective measure for the prevention of Surgical Site Infections (SSI), where indicated. However, its inappropriate use contributes significantly to total antibiotic consumption in hospitals and has been associated with...