In the case of suspected late-onset autoimmune diabetes (LADA) or gestational diabetes mellitus, the search for anti-insular cell antibodies (ICA) and anti-insulin antibodies (IAA) should not be performed.

Nov 16, 2018

In the case of suspected late-onset autoimmune diabetes (LADA) or gestational diabetes mellitus, the search for anti-insular cell antibodies (ICA) and anti-insulin antibodies (IAA) should not be performed.

Type of practice

Laboratory tests

Age

Adult, Geriatric, Pediatric

Topic Area

Laboratory Medicine

Search instead simultaneously for anti-GAD, anti-IA2 and anti-ZnT8 antibodies. The finding of even one antibody positivity among anti-GAD, anti-IA2 and anti-ZnT8 is a diagnostic criterion of LADA and suggests an autoimmune pathogenesis in gestational diabetes mellitus.

Sources

1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014 Jan;37 Suppl 1:S81-90. doi: 10.2337/dc14-S081.
2. Buzzetti R, Zampetti S, Maddaloni E. Adult-onset autoimmune diabetes: current knowledge and implications for management. Nat Rev Endocrinol 2017; 13:674-86. doi: 10.1038/nrendo.2017.99.
3. de Leiva A, Mauricio D, Corcoy R. Diabetes-related autoantibodies and gestational diabetes. Diabetes Care 2007; 30 (Suppl 2):S127-33. doi: 10.2337/dc07-s204. Erratum in: Diabetes Care 2007; 30:3154. PMID: 17596460.
4. The management of type 1 diabetes in adults. a consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2021; 44:2589-625. doi.org/10.2337/dci21-0043

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Attention. Please note that these items are provided only for information and are not intended as a substitute for consultation with a clinician. Patients with any specific questions about the items on this list or their individual situation should consult their clinician.