Don’t request the determination of serum biomarkers like CEA, CA-125, HE4, CA-15.3, -fetoprotein or CA-19.9 for the diagnosis of neoplastic disease in asymptomatic patients.
The diagnostic sensitivity and specificity of these biomarkers are not sufficient to allow their use (diagnosis, screening, case-finding) in a population with a low prevalence of neoplastic diseases. Their use is recommended for the monitoring of the neoplasms that express the specific biomarker (Colon – rectal: CEA; Ovarian: CA-125 and / or HE4; Breast cancer: CA-15.3; Hepatocarcinoma: -fetoprotein; Pancreatic: CA-19.9).
1. Sturgeon CM, Diamandis EP. Use of tumor markers in clinical practice: quality requirements. Disponibile alla pagina: https://academic.oup.com/clinchem/article/54/8/e1/5628779?login=false [citato 26 aprile 2023].
2. Gion M, Trevisiol C, Fabricio AS. Appropriateness of tumor marker request: a case of study. Ann Transl Med 2017;5:274. doi: 10.21037/atm.2017.0.
3. Gion M, Treisiol C, Rainato G.et al. Marcatori circolanti in oncologia Guida all’uso clinico appropriato. Quaderni di Monitor 2016. Disponibile alla pagina: https://www.agenas.gov.it/images/agenas/monitor/quaderno/pdf/16_Quaderno_Marcatori_tumorali.pdf [citato 26 aprile 2023].
Attention. Please note that these items are provided only for information and are not intended as a substitute for consultation with a clinician. Patients with any specific questions about the items on this list or their individual situation should consult their clinician.