Do not use the brain single photon emission tomography with tracers for dopaminergic transporters (DAT-SPECT) for the prognosis and to ascertain the progression of Parkinson’s disease.

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The DaTscan, a dopamine transporter (DAT) single photon emission computerized tomography (SPECT) imaging technique, proved to be valid in the differential diagnosis between Parkinson’s disease and selected neurological conditions (essential tremor, dystonic tremor and psychogenic parkinsonism). However, several studies have shown that there is insufficient evidence to support the use of DaTscan as a prognostic factor or as a measure of disease progression in Parkinson’s disease


1. Kaasinen V et al. Striatal dopamine in Parkinson disease: A meta-analysis of imaging studies. Ann Neurol 2017 Nov 22.
2. Scherfler C et al. Role of DAT-SPECT in the diagnostic work up of parkinsonism. Mov Disord. 2007 Jul 15;22(9):1229-38.

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