Do not neglect to offer radiotherapy delivered with hypofractionated schedules when the scientific evidence is already available.

Type of practice

Other treatments

Topic Area


Several clinical studies reported that moderately hypofractionated radiation therapy (reducing the total number of fractions with daily fraction >2Gy) may be as effective as conventional fractionation in selected subgroups of patients affected by early stage breast or prostate cancer treated with curative intent. Furthermore, stereotactic radiation treatment seems to be superior to conventional approach in early stage unresectable non small cell lung cancer.
Hypofractionated schemes, being as effective as the conventional ones, may be less expensive in terms of economic and social costs, increasing patient’ compliance and reducing the waiting list of the Radiotherapy Centres.


1. .Morgan SC et al. Hypofractionated Radiation Therapy for Localized Prostate Cancer: Executive Summary of an ASTRO, ASCO and AUA Evidence-Based Guideline. J Urol 2019 Mar;201(3):528-534.
2. Mottet N. et al. EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur Urol 2021 Feb;79(2):243-262
3. Fang M et al. Hypofractionated and hyper-hypofractionated radiation therapy in postoperative breast cancer treatment. Rev Assoc Med Bras (1992) 2020 Sep;66(9):1301-1306
4. Ball D. et al. Stereotactic ablative radiotherapy versus standard radiotherapy in stage 1 non-small-cell lung cancer (TROG 09.02 CHISEL): a phase 3, open-label, randomised controlled trial. Lancet Oncol 2019;20:494-503.



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