Do not perform creatinine clearance tests in situations where it is impossible to ensure an accurate urine collection, or when it is not necessary to measure urinary creatinine excretion. In such cases, it is preferable to assess renal function by calculating the eGFR (the volume of the filtrate).
Clearance (or the volume of plasma from which a given substance – creatinine in the case in point – is completely removed per unit of time) is measured using a mathematical formula comprising four factors: blood creatinine concentration; urinary creatinine...
Don’t perform screening tests of polymorphisms of factor V (Leiden) and Factor II (G20210A) in unselected patients, like all patients with only one episodes of venous thrombosis, in healthy subjects or in pregnant women with no specific anamnestic signs or before to start a treatment with oral contraceptives.
According to national and international recommendations and guidelines, testing should not be performed outside of specific medical conditions, e.g.: episodes of venous thrombosis at an early age or the presence of strong familial history, with two or more affected...
Don’t perform HLA genotyping in the presence of established diagnosis of celiac disease or for screening purpose.
HLA-DQ2/DQ8 genotyping is appropriate only in cases of uncertain diagnosis and in subjects with increased risk, like family members of celiac patients (to exclude from subsequent repeated controls the subjects who are negative) and patients with a disease implying an...
Don’t perform genetic tests for monogenic diseases without specific indication both in the physiological procreation or by assisted reproduction technology (ART).
Only in the case where the geneticist recognizes a reproductive risk for a specific monogenic disease, the genetic test for that single disease should be performed on the component at risk. Whether a monogenic autosomal recessive disease is present, the test should be...The campaign DOING MORE DOES NOT MEAN DOING BETTER – CHOOSING WISELY ITALY is promoted by Italy’s Slow Medicine
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