Do not require anti-Thyroperoxidase (AbTPO) and anti-Thyroglobulin (AbTg) antibodies together in suspected autoimmune thyroiditis, only AbTPO.
Prevailing clinical and laboratory literature and authoritative guidelines state that AbTg are less useful than AbTPO and are rarely present without AbTPO. The presence of AbTPO associated or not with AbTg confirms the diagnosis of Auto-Immune Thyroiditis (AHI) but...
Do not measure serum cortisol and plasma corticotropin (ACTH) at random times during the day as first-line tests in suspected Cushing’s syndrome.
For screening of Cushing’s syndrome it is recommended to use one of the following three tests: urinary cortisol (at least two 24-hour collections), nocturnal salivary cortisol (two samples on two different days), serum cortisol after overnight dexamethasone 1 mg...
Do not screen asymptomatic subjects. Do not request an extended panel of thyroid function tests in suspected thyroid function impairment; limit to TSH or TSH Reflex in all cases where it is not contraindicated. Do not require FT3 determination for monitoring levothyroxine therapy in patients with hypothyroidism.
There is currently insufficient evidence to assess the benefit-harm ratio of screening for thyroid dysfunction in asymptomatic adults. Extensive panels of thyroid function tests used in hospital and, in particular, outpatient settings have been found to be less...
Do not perform creatinine clearance tests in situations where it is impossible to ensure an accurate urine collection, or when it is not necessary to measure urinary creatinine excretion. In such cases, it is preferable to assess renal function by calculating the eGFR (the volume of the filtrate).
Clearance (or the volume of plasma from which a given substance – creatinine in the case in point – is completely removed per unit of time) is measured using a mathematical formula comprising four factors: blood creatinine concentration; urinary creatinine...The campaign DOING MORE DOES NOT MEAN DOING BETTER – CHOOSING WISELY ITALY is promoted by Italy’s Slow Medicine
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