Do not use the determination of 25OH vitamin D (25OH-D) as a routine or screening test to determine the status of hypovitaminosis without a specific clinical indication.
According to documents produced by international and national regulatory bodies the measurement of 25OH-D should be reserved for: – a small number of patients with persistent symptoms of profound asthenia, myalgias, diffuse or localised bone pain suspicious for...
Do not require urinary vanillymandelic acid and plasma and/or urinary catecholamines for diagnosis of pheochromocytoma-paraganglioma.
For the diagnosis of pheochromocytoma-paraganglioma require free plasma metanephrines and, if these are not available, fractionated urinary metanephrines. The remarkable sensitivity of plasma and urinary metanephrines allows the diagnosis to be excluded when they are...
Do not require anti-Thyroperoxidase (AbTPO) and anti-Thyroglobulin (AbTg) antibodies together in suspected autoimmune thyroiditis, only AbTPO.
Prevailing clinical and laboratory literature and authoritative guidelines state that AbTg are less useful than AbTPO and are rarely present without AbTPO. The presence of AbTPO associated or not with AbTg confirms the diagnosis of Auto-Immune Thyroiditis (AHI) but...
Do not measure serum cortisol and plasma corticotropin (ACTH) at random times during the day as first-line tests in suspected Cushing’s syndrome.
For screening of Cushing’s syndrome it is recommended to use one of the following three tests: urinary cortisol (at least two 24-hour collections), nocturnal salivary cortisol (two samples on two different days), serum cortisol after overnight dexamethasone 1 mg...The campaign DOING MORE DOES NOT MEAN DOING BETTER – CHOOSING WISELY ITALY is promoted by Italy’s Slow Medicine
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