Corticosteroids have a strong antipyretic and anti-inflammatory effect. However, their use must be reserved to conditions in which the severity of the anti-inflammatory response threatens the child’s health. These drugs must not be used for treatment of a child with fever due to frequent upper-respiratory infections typical of pre-school age. Systemic corticosteroid medications act by exercising a strong immunosuppressive effect and it could cause opportunistic infections, and/or it could worsen viral infections. The decision of prescribing a corticosteroid therapy must consider potential risks, and it should strongly be avoided treating fever of unknown origin (FUO).