Don’t routinely request creatin kinase-MB (CK-MB), total creatin kinase (CK), aspartato transaminase (AST), lactic-dehydrogenase (LDH) e myoglobin diagnosing Acute Coronary Syndromes (ACS).

Don’t routinely request creatin kinase-MB (CK-MB), total creatin kinase (CK), aspartato transaminase (AST), lactic-dehydrogenase (LDH) e myoglobin diagnosing Acute Coronary Syndromes (ACS).

Type of practice

Laboratory tests

Age

Adult, Geriatric

Topic Area

Laboratory Medicine

The cardio-specific troponins (cTn) are considered the markers of choice for the diagnosis of Myocardial Infarction (MI) and Acute Coronary Syndromes (ACS) on the basis of their specificity, sensitivity (both analytical and clinical) and negative predictive value (NPV), and other markers are considered not necessary. Diagnosing ACS depends on the integration of clinical presentation, ECG and biomarkers.

Sources

1. Malloggi L, Cappelletti P, Manno M, et al. Raccomandazioni del GDS MM SIPMeL per l’uso dei biomarcatori cardiaci nella diagnostica di NSTEMI. Parte prima: cosa dicono le linee guida. Riv Ital Med Lab 2020;16:250-62.
2. Malloggi L, Cappelletti P, Moretti M, et al. Raccomandazioni del GDS MM SIPMEL per l’uso dei biomarcatori cardiaci in NSTEMI. Parte seconda: evidenze nella diagnosi. Riv Ital Med Lab 2020;16:263-88.
3. Malloggi L, Cappelletti P, Burgio MA, et al. Raccomandazioni del GdS MM SIPMeL per l’uso dei marcatori miocardiaci nella diagnostica di NSTEMI. Parte terza: prognosi e stratificazione del rischio. Riv Ital Med Lab 2020;16:289-304.

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Attention. Please note that these items are provided only for information and are not intended as a substitute for consultation with a clinician. Patients with any specific questions about the items on this list or their individual situation should consult their clinician.