Do not search for IgA class antibodies to deamidated gliadin peptide (DGP) to screen for celiac disease in the general population.
In people following a gluten-containing diet, the test for IgA anti-gliadin deamidated peptide (GPD) antibodies has lower diagnostic sensitivity and specificity for celiac disease than the test for IgA anti-transglutaminase (TG) antibodies. Therefore, the test for IgA anti-TG antibodies, together with or preceded by the measurement of total serum IgA to exclude selective IgA deficiency, is considered the best first-level screening test for celiac disease. The determination of IgA anti-endomysial (EMA) antibodies is an excellent confirmatory test.
Sources
1. Rubio-Tapia A, Hill ID, Semrad C, et al. American College of Gastroenterology guidelines update: diagnosis and management of celiac disease. Am J Gastroenterol 2023; 118:59-76. doi: 10.14309/ajg.0000000000002075.
2. Catassi C, Verdu EF, Bai JC, et al. Coeliac disease. Lancet 2022; 399:2413-26. doi: 10.1016/S0140-6736(22)00794-2.
3. Al-Toma A, Volta U, Auricchio R, et al. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterol J 2019; 7:583-613. doi: 10.1177/2050640619844125.
4. Zingone F, Maimaris S, Auricchio R, et al. Guidelines of the Italian societies of gastroenterology on the diagnosis and management of coeliac disease and dermatitis herpetiformis. Dig Liver Dis 2022; 54:1304-19. doi: 10.1016/j.dld.2022.06.023.
5. Husby S, Koletzko S, Korponay-Szabó I, et al. European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr 2020; 70:141-56. doi: 10.1097/MPG.0000000000002497.
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PDFAttention. Please note that these items are provided only for information and are not intended as a substitute for consultation with a clinician. Patients with any specific questions about the items on this list or their individual situation should consult their clinician.
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