Do not search for IgA class antibodies to deamidated gliadin peptide (DGP) to screen for celiac disease in the general population.

Nov 16, 2018

Do not search for IgA class antibodies to deamidated gliadin peptide (DGP) to screen for celiac disease in the general population.

Type of practice

Laboratory tests

Age

Adult, Geriatric, Pediatric

Topic Area

Laboratory Medicine

In people following a gluten-containing diet, the test for IgA anti-gliadin deamidated peptide (GPD) antibodies has lower diagnostic sensitivity and specificity for celiac disease than the test for IgA anti-transglutaminase (TG) antibodies. Therefore, the test for IgA anti-TG antibodies, together with or preceded by the measurement of total serum IgA to exclude selective IgA deficiency, is considered the best first-level screening test for celiac disease. The determination of IgA anti-endomysial (EMA) antibodies is an excellent confirmatory test.

Sources

1. Rubio-Tapia A, Hill ID, Semrad C, et al. American College of Gastroenterology guidelines update: diagnosis and management of celiac disease. Am J Gastroenterol 2023; 118:59-76. doi: 10.14309/ajg.0000000000002075.
2. Catassi C, Verdu EF, Bai JC, et al. Coeliac disease. Lancet 2022; 399:2413-26. doi: 10.1016/S0140-6736(22)00794-2.
3. Al-Toma A, Volta U, Auricchio R, et al. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterol J 2019; 7:583-613. doi: 10.1177/2050640619844125.
4. Zingone F, Maimaris S, Auricchio R, et al. Guidelines of the Italian societies of gastroenterology on the diagnosis and management of coeliac disease and dermatitis herpetiformis. Dig Liver Dis 2022; 54:1304-19. doi: 10.1016/j.dld.2022.06.023.
5. Husby S, Koletzko S, Korponay-Szabó I, et al. European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr 2020; 70:141-56. doi: 10.1097/MPG.0000000000002497.

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Attention. Please note that these items are provided only for information and are not intended as a substitute for consultation with a clinician. Patients with any specific questions about the items on this list or their individual situation should consult their clinician.