For the management of vascular access, in particular for washing and closing operations (Flushing and locking) don’t use syringes with direct filling from the IV fluid solution bottle, but prefer the use of pre-filled syringes.

Type of practice

Other health practices


Topic Area


IV solution pre-filled syringes in vascular access management offer several advantages over syringes filled directly from an IV fluid solution bottle. First, they decrease the risk of catheter-related infections, simplifying the procedure and reducing time at the bedside. They also facilitate the management of vascular access, avoiding complications such as occlusion, thrombosis or infection. Finally, they reduce the use of disposable plastic and the volume of waste. The recommendation applies to all types of vascular access, both central and peripheral.


1. Nickel B, Gorski L, Kleidon T, et al. Infusion Therapy Standards of Practice, 9th Edition. Journal of Infusion Nursing. 2024;47(1S):p S1-S285
2. Bertoglio S, Rezzo R, Merlo FD, et al. Pre-filled normal saline syringes to reduce totally implantable venous access device-associated bloodstream infection: a single institution pilot study. J Hosp Infect. 2013;84:85-88
3. Saliba P, Cuervo G, Hornero A, et al. The impact of flushing with pre-filled saline syringes on the incidence of peripheral venous catheter failure: A quasi-experimental study. J Vasc Access. 2020;21(4):490-496



Attention. Please note that these items are provided only for information and are not intended as a substitute for consultation with a clinician. Patients with any specific questions about the items on this list or their individual situation should consult their clinician.