In everyday practice disposable gloves are used and changed inappropriately (e.g., changing sheets, food and beverage administration, administering oral medicines, patient transport, etc.). These behaviours can increase the spread of microorganisms and their consequent increased resistance. Hands are the main vehicle for contact transmission. Hand hygiene using alcohol rubbing is the most effective means of preventing its spread, and in particular with patients carrying multi-drug resistant organisms (MDRO).In fact, the failure to change gloves and the lack of hand hygiene after contact with the patient poses a serious risk of infectious complications. Health education and information on rubbing hands with alcohol and the correct ways of using gloves addressed to healthcare staff, patients and caregivers is crucial in this regard.