{"id":5689,"date":"2020-10-27T19:24:34","date_gmt":"2020-10-27T18:24:34","guid":{"rendered":"https:\/\/choosingwiselyitaly.org\/?post_type=raccomandazione-prof&#038;p=5689"},"modified":"2020-10-27T19:24:34","modified_gmt":"2020-10-27T18:24:34","slug":"do-not-perform-genetic-testing-for-y-chromosome-microdeletions-as-a-screening-test-for-all-male-patients-with-reproductive-problems","status":"publish","type":"raccomandazione-prof","link":"https:\/\/choosingwiselyitaly.org\/en\/raccomandazione-prof\/do-not-perform-genetic-testing-for-y-chromosome-microdeletions-as-a-screening-test-for-all-male-patients-with-reproductive-problems\/","title":{"rendered":"Do not perform genetic testing for Y chromosome microdeletions as a screening test for all male patients with reproductive problems"},"content":{"rendered":"<p>Microdeletions of the Y chromosome are long arm submicroscopic alterations that cause the loss of different genes for the control of spermatogenesis. These microdeletions, &#8220;de novo&#8221; in most cases, can cause alterations in spermatogenesis ranging from complete azoospermia to severe oligozoospermia. The detection rate (DR) of this type of test is about 10% when performed on selected patients, so when the test is used with &#8220;diagnostic&#8221; value. Conversely, if the test is used as a &#8220;screening&#8221; test for all male patients with reproductive problems, the DR drops below 2%.<br \/>\nGood practice: do not require the test for the detection of Y microdeletions in normospermic patients, with mild oligozoospermia (sperm count &gt;15ML\/ml) or with obstructive azoospermia, even if initiated to a path of Medically Assisted Reproduction (MAP), and in any case before having excluded the presence of karyotype abnormalities or non-genetic causes of sterility.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_wpml_word_count":["{\"total\":281,\"to_translate\":{\"it\":281}}"],"_wpv_contains_gutenberg_views":[""],"_layouts_template":["modello-per-raccomandazioni-professionista"],"_wp_page_template":["default"],"_edit_lock":["1603822955:2"],"_edit_last":["2"],"_wpml_media_featured":["1"],"_wpml_media_duplicate":["1"],"_wpml_location_migration_done":["1"],"_yoast_wpseo_primary_eta":["96"],"_yoast_wpseo_primary_disciplina":["122"],"_yoast_wpseo_primary_tipologia":["135"],"_yoast_wpseo_content_score":["60"],"_yoast_wpseo_focuskeywords":["[]"],"_yoast_wpseo_keywordsynonyms":["[\"\"]"],"wpcf-pacchetto":["SIGU #2"],"wpcf-bibliografia":["1.\tMolecular and clinical characterization of Y chromosome\u00c2 microdeletions\u00c2 in infertile men: a 10-year experience in Italy. <https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17213277> Ferlin A, Arredi B, Speltra E, Cazzadore C, Selice R, Garolla A, Lenzi A, Foresta C. J Clin Endocrinol Metab. 2007 Mar;92(3):762-70.\r\n2.\tGenetic testing\u00c2 in couples undergoing assisted reproduction technique protocols https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23495986\r\nStuppia L, Gatta V, Antonucci I, Giuliani R, Scioletti AP, Palka G. Expert Opin Med Diagn. 2009 Sep;3(5):571-83.\r\n3.\tLinee Guida SIGU su \u00e2\u20ac\u0153 Test genetici nel percorso della procreazione medicalmente assistita (PMA)"],"wpcf-posizione-prof":["2"],"wpcf-collegare":["N"],"wpcf-link-intercheck-prof":["N"],"wpcf-pdfpdf-prosfessionista":["https:\/\/choosingwiselyitaly.org\/wp-content\/uploads\/2020\/10\/scheda-SIGU-2-english.pdf"],"wpcf-area-ordinamento":["Human Genetics"]},"eta":[{"term_id":96,"name":"Adult","slug":"adult","term_group":0,"term_taxonomy_id":96,"taxonomy":"eta","description":"","parent":0,"count":272,"filter":"raw"}],"disciplina":[122],"tipologia":"Laboratory tests","class_list":["post-5689","raccomandazione-prof","type-raccomandazione-prof","status-publish","hentry","eta-adult","disciplina-human-genetics","tipologia-laboratory-tests"],"_links":{"self":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/raccomandazione-prof\/5689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/raccomandazione-prof"}],"about":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/types\/raccomandazione-prof"}],"wp:attachment":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/media?parent=5689"}],"wp:term":[{"taxonomy":"eta","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/eta?post=5689"},{"taxonomy":"disciplina","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/disciplina?post=5689"},{"taxonomy":"tipologia","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/tipologia?post=5689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}