{"id":3005,"date":"2018-11-16T12:09:17","date_gmt":"2018-11-16T11:09:17","guid":{"rendered":"https:\/\/choosingwiselyitaly.org\/?post_type=raccomandazione-prof&#038;p=3005"},"modified":"2025-10-09T18:33:13","modified_gmt":"2025-10-09T16:33:13","slug":"invasive-endoscopic-investigation-with-multiple-biopsies-should-not-be-performed-in-all-patients-suspected-of-autoimmune-gastritis-but-only-in-those-presenting-with-alteration-of-serum-markers-of-gast","status":"publish","type":"raccomandazione-prof","link":"https:\/\/choosingwiselyitaly.org\/en\/raccomandazione-prof\/invasive-endoscopic-investigation-with-multiple-biopsies-should-not-be-performed-in-all-patients-suspected-of-autoimmune-gastritis-but-only-in-those-presenting-with-alteration-of-serum-markers-of-gast\/","title":{"rendered":"Do not search for IgA class antibodies to deamidated gliadin peptide (DGP) to screen for celiac disease in the general population."},"content":{"rendered":"<p>In people following a gluten-containing diet, the test for IgA anti-gliadin deamidated peptide (GPD) antibodies has lower diagnostic sensitivity and specificity for celiac disease than the test for IgA anti-transglutaminase (TG) antibodies. Therefore, the test for IgA anti-TG antibodies, together with or preceded by the measurement of total serum IgA to exclude selective IgA deficiency, is considered the best first-level screening test for celiac disease. The determination of IgA anti-endomysial (EMA) antibodies is an excellent confirmatory test.<\/p>\n","protected":false},"featured_media":3022,"template":"","meta":{"_edit_lock":["1760027472:2"],"_edit_last":["2"],"_wpml_media_featured":["1"],"_wpml_media_duplicate":["1"],"_yst_prominent_words_version":["1"],"_thumbnail_id":["3022"],"_wpml_word_count":["117"],"_yoast_wpseo_primary_eta":[""],"_yoast_wpseo_primary_disciplina":["124"],"_yoast_wpseo_primary_tipologia":[""],"wpcf-pacchetto":["SIPMeL #3"],"wpcf-bibliografia":["1. Rubio-Tapia A, Hill ID, Semrad C, et al. American College of Gastroenterology guidelines update: diagnosis and management of celiac disease. Am J Gastroenterol 2023; 118:59-76. doi: 10.14309\/ajg.0000000000002075.\r\n2. Catassi C, Verdu EF, Bai JC, et al. Coeliac disease. Lancet 2022; 399:2413-26. doi: 10.1016\/S0140-6736(22)00794-2.\r\n3. Al-Toma A, Volta U, Auricchio R, et al. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterol J 2019; 7:583-613. doi: 10.1177\/2050640619844125.\r\n4. Zingone F, Maimaris S, Auricchio R, et al. Guidelines of the Italian societies of gastroenterology on the diagnosis and management of coeliac disease and dermatitis herpetiformis. Dig Liver Dis 2022; 54:1304-19. doi: 10.1016\/j.dld.2022.06.023.\r\n5. Husby S, Koletzko S, Korponay-Szab\u00f3 I, et al. European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr 2020; 70:141-56. doi: 10.1097\/MPG.0000000000002497."],"wpcf-posizione-prof":["4"],"wpcf-collegare":["N"],"wpcf-link-intercheck-prof":["N"],"wpcf-area-ordinamento":["Laboratory Medicine"],"_yoast_wpseo_content_score":["90"],"_yoast_wpseo_focuskeywords":["[]"],"_yoast_wpseo_keywordsynonyms":["[\"\"]"],"_wpml_location_migration_done":["1"],"_layouts_template":["layout-for-raccomandazioni-professionista"],"_wp_page_template":["default"],"cmplz_hide_cookiebanner":[""],"wpcf-parole-chiave-prof":[""],"wpcf-pdfpdf-prosfessionista":["https:\/\/choosingwiselyitaly.org\/wp-content\/uploads\/2018\/11\/Scheda-GdS-AI-SIPMeL-2025-inglese-versione-finale-ok.pdf"],"_wpv_contains_gutenberg_views":[""],"_et_dynamic_cached_shortcodes":["a:4:{i:0;s:13:\"et_pb_section\";i:1;s:9:\"et_pb_row\";i:2;s:12:\"et_pb_column\";i:50;s:10:\"et_pb_text\";}"],"_et_dynamic_cached_attributes":["a:0:{}"],"et_enqueued_post_fonts":["a:3:{s:6:\"family\";a:1:{s:15:\"et-gf-work-sans\";s:136:\"Work+Sans:100,200,300,regular,500,600,700,800,900,100italic,200italic,300italic,italic,500italic,600italic,700italic,800italic,900italic\";}s:6:\"subset\";a:2:{i:0;s:5:\"latin\";i:1;s:9:\"latin-ext\";}s:9:\"cache_key\";s:75:\"{\"gph\":-1,\"divi\":\"4.27.6\",\"wp\":\"6.8.5\",\"enable_all_character_sets\":\"false\"}\";}"],"_et_builder_module_features_cache":["a:2:{i:0;s:84:\"{\"gph\":-1,\"divi\":\"4.27.6\",\"wp\":\"6.8.5\",\"tb\":{\"6368\":\"2023-03-16 11:14:40\"},\"wpe\":[]}\";i:1;a:4:{s:46:\"et_pb_section_91fa936ebb617131b2b56a2ba502d8b0\";a:5:{s:4:\"cuma\";b:1;s:4:\"mawi\";b:1;s:4:\"bosh\";b:1;s:5:\"mapac\";b:1;s:4:\"anim\";b:1;}s:42:\"et_pb_row_059cd63bb2a463cb90b14e6c9dcc0566\";a:3:{s:4:\"mawi\";b:1;s:4:\"bosh\";b:1;s:4:\"anim\";b:1;}s:45:\"et_pb_column_538b686ce80a620826cc9f316c3ac5c4\";a:3:{s:4:\"bosh\";b:1;s:3:\"pos\";b:1;s:4:\"anim\";b:1;}s:43:\"et_pb_text_0b5d770c54ecf96cc731c8b442804e81\";a:7:{s:4:\"glde\";a:10:{s:14:\"text_font_size\";s:2:\"14\";s:19:\"text_letter_spacing\";s:3:\"0px\";s:16:\"text_line_height\";s:5:\"1.7em\";s:16:\"header_font_size\";s:4:\"30px\";s:21:\"header_letter_spacing\";s:3:\"0px\";s:18:\"header_line_height\";s:3:\"1em\";s:15:\"background_size\";s:5:\"cover\";s:19:\"background_position\";s:6:\"center\";s:17:\"background_repeat\";s:9:\"no-repeat\";s:16:\"background_blend\";s:6:\"normal\";}s:4:\"foop\";b:1;s:4:\"tesh\";b:1;s:4:\"mawi\";b:1;s:4:\"bosh\";b:1;s:3:\"pos\";b:1;s:4:\"anim\";b:1;}}}"]},"eta":[{"term_id":96,"name":"Adult","slug":"adult","term_group":0,"term_taxonomy_id":96,"taxonomy":"eta","description":"","parent":0,"count":272,"filter":"raw"},{"term_id":97,"name":"Geriatric","slug":"geriatric","term_group":0,"term_taxonomy_id":97,"taxonomy":"eta","description":"","parent":0,"count":242,"filter":"raw"},{"term_id":95,"name":"Pediatric","slug":"pediatric","term_group":0,"term_taxonomy_id":95,"taxonomy":"eta","description":"","parent":0,"count":172,"filter":"raw"}],"disciplina":[124],"tipologia":"Laboratory tests","class_list":["post-3005","raccomandazione-prof","type-raccomandazione-prof","status-publish","has-post-thumbnail","hentry","eta-adult","eta-geriatric","eta-pediatric","disciplina-laboratory-medicine","tipologia-laboratory-tests"],"_links":{"self":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/raccomandazione-prof\/3005","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/raccomandazione-prof"}],"about":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/types\/raccomandazione-prof"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/media\/3022"}],"wp:attachment":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/media?parent=3005"}],"wp:term":[{"taxonomy":"eta","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/eta?post=3005"},{"taxonomy":"disciplina","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/disciplina?post=3005"},{"taxonomy":"tipologia","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/tipologia?post=3005"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}