{"id":3003,"date":"2018-11-16T12:05:59","date_gmt":"2018-11-16T11:05:59","guid":{"rendered":"https:\/\/choosingwiselyitaly.org\/?post_type=raccomandazione-prof&#038;p=3003"},"modified":"2025-10-09T18:29:20","modified_gmt":"2025-10-09T16:29:20","slug":"do-not-request-anti-tpo-anti-thyroid-peroxidase-and-anti-tg-anti-thyroglobulin-antibody-tests-in-the-monitoring-of-autoimmune-thyroid-disease","status":"publish","type":"raccomandazione-prof","link":"https:\/\/choosingwiselyitaly.org\/en\/raccomandazione-prof\/do-not-request-anti-tpo-anti-thyroid-peroxidase-and-anti-tg-anti-thyroglobulin-antibody-tests-in-the-monitoring-of-autoimmune-thyroid-disease\/","title":{"rendered":"Do not order the HEp-2 indirect immunofluorescence test for ANA (antibodies to cellular antigens) as a screening test in patients with suspected autoimmune myositis."},"content":{"rendered":"<p>The use of ANA IIF as the sole screening method for MSA\/MAA (Myositis-Specific Ab\/Myositis-Associated Ab) is not recommended due to low sensitivity, very low specificity and\/or lack of antigen expression by HEp-2 cells. Therefore, in case of clinical suspicion of autoimmune myositis, the first-line serological test to be performed should be a multispecific immunometric test for the full spectrum of MSA\/MAA antibodies.<\/p>\n","protected":false},"featured_media":3022,"template":"","meta":{"_edit_lock":["1760027242:2"],"_edit_last":["2"],"_wpml_media_featured":["1"],"_wpml_media_duplicate":["1"],"_yst_prominent_words_version":["1"],"_thumbnail_id":["3022"],"_wpml_word_count":["100"],"_yoast_wpseo_primary_eta":[""],"_yoast_wpseo_primary_disciplina":["124"],"_yoast_wpseo_primary_tipologia":[""],"wpcf-pacchetto":["SIPMeL #3"],"wpcf-bibliografia":["1. Damoiseaux J, Vulsteke JB, Tseng CW, et al. Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays. Autoimmun Rev 2019; 18:293-305. doi: 10.1016\/j.autrev.2018.10.004. \r\n2. Palterer B, Vitiello G, Carraresi A, et al. Bench to bedside review of myositis autoantibodies. Clin Mol Allergy 2018; 16:5 https:\/\/doi.org\/10.1186\/s12948-018-0084-9.\r\n3. Damoiseaux J, Mammen AL, Piette Y, et al; ENMC 256th Workshop Study Group. 256th ENMC international workshop: Myositis specific and associated autoantibodies (MSA-ab): Amsterdam, The Netherlands, 8-10 October 2021. Neuromuscul Disord 2022; 32:594-608. doi: 10.1016\/j.nmd.2022.05.011."],"wpcf-posizione-prof":["2"],"wpcf-collegare":["N"],"wpcf-link-intercheck-prof":["N"],"wpcf-area-ordinamento":["Laboratory Medicine"],"_yoast_wpseo_content_score":["90"],"_yoast_wpseo_focuskeywords":["[]"],"_yoast_wpseo_keywordsynonyms":["[\"\"]"],"_wpml_location_migration_done":["1"],"_layouts_template":["layout-for-raccomandazioni-professionista"],"_wp_page_template":["default"],"cmplz_hide_cookiebanner":[""],"wpcf-parole-chiave-prof":[""],"wpcf-pdfpdf-prosfessionista":["https:\/\/choosingwiselyitaly.org\/wp-content\/uploads\/2018\/11\/Scheda-GdS-AI-SIPMeL-2025-inglese-versione-finale-ok.pdf"],"_wpv_contains_gutenberg_views":[""],"_et_dynamic_cached_shortcodes":["a:4:{i:0;s:13:\"et_pb_section\";i:1;s:9:\"et_pb_row\";i:2;s:12:\"et_pb_column\";i:50;s:10:\"et_pb_text\";}"],"_et_dynamic_cached_attributes":["a:0:{}"],"et_enqueued_post_fonts":["a:3:{s:6:\"family\";a:1:{s:15:\"et-gf-work-sans\";s:136:\"Work+Sans:100,200,300,regular,500,600,700,800,900,100italic,200italic,300italic,italic,500italic,600italic,700italic,800italic,900italic\";}s:6:\"subset\";a:2:{i:0;s:5:\"latin\";i:1;s:9:\"latin-ext\";}s:9:\"cache_key\";s:75:\"{\"gph\":-1,\"divi\":\"4.27.6\",\"wp\":\"6.9.4\",\"enable_all_character_sets\":\"false\"}\";}"],"_et_builder_module_features_cache":["a:2:{i:0;s:84:\"{\"gph\":-1,\"divi\":\"4.27.6\",\"wp\":\"6.9.4\",\"tb\":{\"6368\":\"2023-03-16 11:14:40\"},\"wpe\":[]}\";i:1;a:4:{s:46:\"et_pb_section_91fa936ebb617131b2b56a2ba502d8b0\";a:5:{s:4:\"cuma\";b:1;s:4:\"mawi\";b:1;s:4:\"bosh\";b:1;s:5:\"mapac\";b:1;s:4:\"anim\";b:1;}s:42:\"et_pb_row_059cd63bb2a463cb90b14e6c9dcc0566\";a:3:{s:4:\"mawi\";b:1;s:4:\"bosh\";b:1;s:4:\"anim\";b:1;}s:45:\"et_pb_column_538b686ce80a620826cc9f316c3ac5c4\";a:3:{s:4:\"bosh\";b:1;s:3:\"pos\";b:1;s:4:\"anim\";b:1;}s:43:\"et_pb_text_0b5d770c54ecf96cc731c8b442804e81\";a:7:{s:4:\"glde\";a:10:{s:14:\"text_font_size\";s:2:\"14\";s:19:\"text_letter_spacing\";s:3:\"0px\";s:16:\"text_line_height\";s:5:\"1.7em\";s:16:\"header_font_size\";s:4:\"30px\";s:21:\"header_letter_spacing\";s:3:\"0px\";s:18:\"header_line_height\";s:3:\"1em\";s:15:\"background_size\";s:5:\"cover\";s:19:\"background_position\";s:6:\"center\";s:17:\"background_repeat\";s:9:\"no-repeat\";s:16:\"background_blend\";s:6:\"normal\";}s:4:\"foop\";b:1;s:4:\"tesh\";b:1;s:4:\"mawi\";b:1;s:4:\"bosh\";b:1;s:3:\"pos\";b:1;s:4:\"anim\";b:1;}}}"]},"eta":[{"term_id":96,"name":"Adult","slug":"adult","term_group":0,"term_taxonomy_id":96,"taxonomy":"eta","description":"","parent":0,"count":277,"filter":"raw"},{"term_id":97,"name":"Geriatric","slug":"geriatric","term_group":0,"term_taxonomy_id":97,"taxonomy":"eta","description":"","parent":0,"count":247,"filter":"raw"},{"term_id":95,"name":"Pediatric","slug":"pediatric","term_group":0,"term_taxonomy_id":95,"taxonomy":"eta","description":"","parent":0,"count":177,"filter":"raw"}],"disciplina":[124],"tipologia":"Laboratory tests","class_list":["post-3003","raccomandazione-prof","type-raccomandazione-prof","status-publish","has-post-thumbnail","hentry","eta-adult","eta-geriatric","eta-pediatric","disciplina-laboratory-medicine","tipologia-laboratory-tests"],"_links":{"self":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/raccomandazione-prof\/3003","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/raccomandazione-prof"}],"about":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/types\/raccomandazione-prof"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/media\/3022"}],"wp:attachment":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/media?parent=3003"}],"wp:term":[{"taxonomy":"eta","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/eta?post=3003"},{"taxonomy":"disciplina","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/disciplina?post=3003"},{"taxonomy":"tipologia","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/tipologia?post=3003"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}