{"id":2914,"date":"2018-10-17T19:08:32","date_gmt":"2018-10-17T17:08:32","guid":{"rendered":"https:\/\/choosingwiselyitaly.org\/raccomandazione-prof\/do-not-perform-urinary-vanilmandelic-acid-and-plasma-and-or-urinary-catecholamines-for-diagnosing-pheochromocytoma\/"},"modified":"2025-04-17T16:18:24","modified_gmt":"2025-04-17T14:18:24","slug":"do-not-measure-serum-cortisol-and-plasma-corticotropin-acth-at-random-times-during-the-day-as-first-line-tests-in-suspected-cushings-syndrome","status":"publish","type":"raccomandazione-prof","link":"https:\/\/choosingwiselyitaly.org\/en\/raccomandazione-prof\/do-not-measure-serum-cortisol-and-plasma-corticotropin-acth-at-random-times-during-the-day-as-first-line-tests-in-suspected-cushings-syndrome\/","title":{"rendered":"Do not measure serum cortisol and plasma corticotropin (ACTH) at random times during the day as first-line tests in suspected Cushing&#8217;s syndrome."},"content":{"rendered":"<p>For screening of Cushing&#8217;s syndrome it is recommended to use one of the following three tests: urinary cortisol (at least two 24-hour collections), nocturnal salivary cortisol (two samples on two different days), serum cortisol after overnight dexamethasone 1 mg suppression test (oDST). This approach is strongly supported by authoritative scientific societies and is aligned with up-to-date and Evidence-Based literature.<\/p>\n","protected":false},"featured_media":3022,"template":"","meta":{"_edit_lock":["1744899365:2"],"_edit_last":["2"],"_wpml_media_duplicate":["0"],"_wpml_media_featured":["0"],"_thumbnail_id":["3022"],"_wpml_word_count":["{\"total\":289,\"to_translate\":{\"it\":289}}"],"_yoast_wpseo_primary_eta":[""],"_yoast_wpseo_primary_disciplina":["124"],"_yoast_wpseo_primary_tipologia":[""],"wpcf-pacchetto":["SIPMeL #2"],"wpcf-bibliografia":["1. Nieman LK, Biller BM, Findling JW, et al. The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2008; 93: 1526-40. DOI: 10.1210\/jc.2008-0125.\r\n2. D\u2019Aurizio F, Tozzoli R, Dorizzi RM, et al. La diagnostica di laboratorio delle malattie del surrene. Raccomandazioni pratiche per la sindrome di Cushing. Riv Ital Med Lab 2015; 11: 132-49. DOI: 10.1007\/s13631-015-0088-0\r\n3.  Galm BP, Qiao N, Klibanski A, et al. Accuracy of laboratory tests for the diagnosis of Cushing syndrome. J Clin Endocrinol Metab 2020; 105:2081\u201394. DOI: 10.1210\/clinem\/dgaa105.\r\n4. Braun LT, Vogel F, Zopp S, et al. Whom Should We Screen for Cushing Syndrome? The Endocrine Society Practice guideline recommendations 2008 revisited. J Clin Endocrinol Metab 2022;107: e3723-30. DOI: 10.1210\/clinem\/dgac379.\r\n5. Centre de r\u00e9f\u00e9rence des maladies rares de la surr\u00e9nale. Extraite du Protocole National de Diagnostic et de Soins (PNDS) Syndrome de Cushing Janvier 2023 [Internet] Available from:   https:\/\/www.has-sante.fr\/upload\/docs\/application\/pdf\/2023-01\/synthese_mg_syndrome_de_cushing.pdf (last accessed March 2024)."],"wpcf-posizione-prof":["3"],"wpcf-collegare":["N"],"wpcf-link-intercheck-prof":["N"],"wpcf-area-ordinamento":["Laboratory Medicine"],"_yoast_wpseo_content_score":["90"],"_yoast_wpseo_focuskeywords":["[]"],"_yoast_wpseo_keywordsynonyms":["[\"\"]"],"_wpml_location_migration_done":["1"],"_layouts_template":["layout-for-raccomandazioni-professionista"],"_wp_page_template":["default"],"cmplz_hide_cookiebanner":[""],"wpcf-parole-chiave-prof":[""],"wpcf-pdfpdf-prosfessionista":["https:\/\/choosingwiselyitaly.org\/wp-content\/uploads\/2018\/10\/Scheda-SIPMeL-gruppo-endocrinologia-2024-english-ok-2.pdf"],"_wpv_contains_gutenberg_views":[""],"_wp_old_slug":["do-not-perform-urinary-vanilmandelic-acid-and-plasma-and-or-urinary-catecholamines-for-diagnosing-pheochromocytoma"],"_et_dynamic_cached_shortcodes":["a:4:{i:0;s:13:\"et_pb_section\";i:1;s:9:\"et_pb_row\";i:2;s:12:\"et_pb_column\";i:50;s:10:\"et_pb_text\";}"],"_et_dynamic_cached_attributes":["a:0:{}"],"et_enqueued_post_fonts":["a:3:{s:6:\"family\";a:1:{s:15:\"et-gf-work-sans\";s:136:\"Work+Sans:100,200,300,regular,500,600,700,800,900,100italic,200italic,300italic,italic,500italic,600italic,700italic,800italic,900italic\";}s:6:\"subset\";a:2:{i:0;s:5:\"latin\";i:1;s:9:\"latin-ext\";}s:9:\"cache_key\";s:75:\"{\"gph\":-1,\"divi\":\"4.27.6\",\"wp\":\"6.8.5\",\"enable_all_character_sets\":\"false\"}\";}"]},"eta":[{"term_id":95,"name":"Pediatric","slug":"pediatric","term_group":0,"term_taxonomy_id":95,"taxonomy":"eta","description":"","parent":0,"count":172,"filter":"raw"}],"disciplina":[124],"tipologia":"Laboratory tests","class_list":["post-2914","raccomandazione-prof","type-raccomandazione-prof","status-publish","has-post-thumbnail","hentry","eta-pediatric","disciplina-laboratory-medicine","tipologia-laboratory-tests"],"_links":{"self":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/raccomandazione-prof\/2914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/raccomandazione-prof"}],"about":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/types\/raccomandazione-prof"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/media\/3022"}],"wp:attachment":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/media?parent=2914"}],"wp:term":[{"taxonomy":"eta","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/eta?post=2914"},{"taxonomy":"disciplina","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/disciplina?post=2914"},{"taxonomy":"tipologia","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/tipologia?post=2914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}