{"id":2884,"date":"2018-10-17T19:08:03","date_gmt":"2018-10-17T17:08:03","guid":{"rendered":"https:\/\/choosingwiselyitaly.org\/raccomandazione-prof\/dont-prescribe-mf-59-adjuvated-influenza-vaccine-in-elderly-people\/"},"modified":"2026-01-29T17:36:19","modified_gmt":"2026-01-29T16:36:19","slug":"dont-prescribe-mf-59-adjuvated-influenza-vaccine-in-elderly-people","status":"publish","type":"raccomandazione-prof","link":"https:\/\/choosingwiselyitaly.org\/en\/raccomandazione-prof\/dont-prescribe-mf-59-adjuvated-influenza-vaccine-in-elderly-people\/","title":{"rendered":"Do not prefer intravenous antibiotic formulations over oral ones if, after 48 hours of therapy, the patient (both pediatric and adult) meets the criteria for IV-to-oral switch, namely: afebrile, able to take oral medication, showing clinical improvement, and not affected by deep bacterial infections at high risk. (Green recommendation)"},"content":{"rendered":"<p>Numerous scientific studies have shown, and several guidelines (NICE, WHO) recommend, that intravenous antibiotic therapy should be promptly switched to oral therapy once the IV-to-oral (IV-PO) switch criteria are met\u2014or discontinued if no longer necessary. The criteria are as follows: <strong>A<\/strong> \u2013 Afebrile, <strong>B<\/strong> \u2013 Able to take oral medications, <strong>C<\/strong> \u2013 Clinically improving, <strong>D<\/strong> \u2013 Not affected by certain deep-seated or high-risk infections (e.g., osteomyelitis, endocarditis, meningitis, empyema, soft tissue infections, septic arthritis, sepsis, abscesses).<br \/>\nUnnecessary continuation of intravenous therapy increases the risk of infection and adverse events, requires more healthcare resources, may prolong hospital stays, and has a greater environmental impact.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"featured_media":2417,"template":"","meta":{"_edit_lock":["1769704665:2"],"_edit_last":["2"],"_wpml_media_duplicate":["0"],"_wpml_media_featured":["0"],"_thumbnail_id":["2417"],"_wpml_word_count":["190"],"_yoast_wpseo_primary_eta":[""],"_yoast_wpseo_primary_disciplina":["121"],"_yoast_wpseo_primary_tipologia":[""],"wpcf-pacchetto":["SIFACT #1"],"wpcf-bibliografia":["1. Waagsbo B, Sundoy A & Paulsen E. Reduction of unnecessary IV antibiotic days using general criteria for antibiotic switch Scand J Infectious Dis 2008; 40: 468-473. doi: 10.1080\/00365540701837134.\r\n2. Gasparetto J, Tuon FF, Dos Santos Oliveira D, et al. Intravenous-to-oral antibiotic switch therapy: a cross-sectional study in critical care units. BMC Infect Dis 2019;19:650. doi: 10.1186\/s12879-019-4280-0.\r\n3. Sze W T, Kong M C. Impact of printed antimicrobial stewardship recommendations on early intravenous to oral antibiotics switch practice in district hospitals. Pharm Pract (Granada) 2018;16:855. doi: 10.18549\/PharmPract.2018.02.855.\r\n4. Mertz D, Koller M, Haller P et al. Outcomes of early switching from intravenous to oral antibiotics on medical wards J Antimicrob Chemother 2009; 64: 188-199. doi: 10.1093\/jac\/dkp131.\r\n5. Schuts EC, Hulscher M, Mouton JW, et al. Current evidence on hospital antimicrobial stewardship objectives: a systematic review and meta-analysis. The Lancet Infectious Diseases 2016;16:847-856. doi: 10.1016\/S1473-3099(16)00065-7."],"wpcf-posizione-prof":["3"],"wpcf-collegare":["N"],"wpcf-link-intercheck-prof":["N"],"wpcf-area-ordinamento":["Clinical Pharmacy and Therapy"],"_yoast_wpseo_content_score":["90"],"_yoast_wpseo_focuskeywords":["[]"],"_yoast_wpseo_keywordsynonyms":["[\"\"]"],"_wpml_location_migration_done":["1"],"_layouts_template":["layout-for-raccomandazioni-professionista"],"_wp_page_template":["default"],"cmplz_hide_cookiebanner":[""],"wpcf-parole-chiave-prof":[""],"wpcf-pdfpdf-prosfessionista":["https:\/\/choosingwiselyitaly.org\/wp-content\/uploads\/2018\/10\/Scheda-SIFACT-2024-english-rev.pdf"],"_wpv_contains_gutenberg_views":[""],"_et_dynamic_cached_shortcodes":["a:4:{i:0;s:13:\"et_pb_section\";i:1;s:9:\"et_pb_row\";i:2;s:12:\"et_pb_column\";i:50;s:10:\"et_pb_text\";}"],"_et_dynamic_cached_attributes":["a:0:{}"],"et_enqueued_post_fonts":["a:3:{s:6:\"family\";a:1:{s:15:\"et-gf-work-sans\";s:136:\"Work+Sans:100,200,300,regular,500,600,700,800,900,100italic,200italic,300italic,italic,500italic,600italic,700italic,800italic,900italic\";}s:6:\"subset\";a:2:{i:0;s:5:\"latin\";i:1;s:9:\"latin-ext\";}s:9:\"cache_key\";s:75:\"{\"gph\":-1,\"divi\":\"4.27.6\",\"wp\":\"6.8.5\",\"enable_all_character_sets\":\"false\"}\";}"]},"eta":[{"term_id":96,"name":"Adult","slug":"adult","term_group":0,"term_taxonomy_id":96,"taxonomy":"eta","description":"","parent":0,"count":272,"filter":"raw"},{"term_id":97,"name":"Geriatric","slug":"geriatric","term_group":0,"term_taxonomy_id":97,"taxonomy":"eta","description":"","parent":0,"count":242,"filter":"raw"},{"term_id":95,"name":"Pediatric","slug":"pediatric","term_group":0,"term_taxonomy_id":95,"taxonomy":"eta","description":"","parent":0,"count":172,"filter":"raw"}],"disciplina":[121],"tipologia":"Drugs","class_list":["post-2884","raccomandazione-prof","type-raccomandazione-prof","status-publish","has-post-thumbnail","hentry","eta-adult","eta-geriatric","eta-pediatric","disciplina-clinical-pharmacy-and-therapy","tipologia-drugs"],"_links":{"self":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/raccomandazione-prof\/2884","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/raccomandazione-prof"}],"about":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/types\/raccomandazione-prof"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/media\/2417"}],"wp:attachment":[{"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/media?parent=2884"}],"wp:term":[{"taxonomy":"eta","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/eta?post=2884"},{"taxonomy":"disciplina","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/disciplina?post=2884"},{"taxonomy":"tipologia","embeddable":true,"href":"https:\/\/choosingwiselyitaly.org\/en\/wp-json\/wp\/v2\/tipologia?post=2884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}