In documented clinical and radiological evidence of dementia, don’t ask for brain SPECT (single-photon emission computed tomography) or 18-FDG PET (fluorodeoxyglucose positron emission tomography) or PET (positron emission tomography) with amyloid markers.

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Topic Area


Brain SPECT investigates brain blood perfusion, the 18-FDG PET investigates the hypometabolism of the cerebral gray matter, the amyloid PET marks amyloid deposits in the brain.In the presence of a documented clinical and radiologic diagnosis of dementia and its nature, potential benefits of the use of these diagnostics are unlikely due to the low possibility of obtaining further data to strengthen evidence.
Otherwise these exams can help in the diagnostic process if no structural dementia changes in the brain MR are reported and/or in atypical clinical presentation (age of onset or evolution), with other diagnostics.


1. Guerra UP, Nobili FM, Padovani A, Perani D, Pupi A, Sorbi S, Trabucchi M. Recommendations from the Italian Interdisciplinar Working Group (AIMN, AIP, SINDEM) for the utilization of amyloid imaging in clinical practice. Neurol Sci 10.1007/s10072-015-2079-3 (Published 24 January 2015

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